Reversed Proteolysis—Proteases as Peptide Ligases
نویسندگان
چکیده
منابع مشابه
Peptide and small molecule inhibitors of HECT-type ubiquitin ligases.
The human genome encodes several hundred E3 ubiquitin ligases containing RING domains, and around 28 containing HECT domains. These enzymes catalyze the transfer of ubiquitin from E2 enzyme thioesters to a huge range of substrates and play crucial roles in many cellular functions. This makes them attractive potential therapeutic targets. However, they have proven difficult to inhibit: very few ...
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ژورنال
عنوان ژورنال: Catalysts
سال: 2020
ISSN: 2073-4344
DOI: 10.3390/catal11010033